Publications by authors named "N Srinivas"
Objective: Family-centered rounds (FCR) is the standard for pediatric communication, but community pediatric hospital medicine services may face barriers in implementation, including offering FCR to families with a language preference other than English (LOE) versus those with an English preference (EP). The goal of our quality improvement project was to increase FCR from 33% to 80% over 1 year.
Methods: Interventions included an FCR checklist integrated into the electronic healthcare record (EHR-FCR checklist), staff education, visual prompts, and interpreters.
Background: Presence of micrometastases in the sentinel lymph node (SLN) is currently used to assess prognosis of melanoma patients. The immunoactivity within the SLN is known to be influenced by the primary tumor (PT), which may in turn impact the SLNs' metastatic state.
Aim: We characterize the temporal dependence and underlying mechanisms of the immunological effects of the PT on the SLN.
Article Synopsis
- Mycosis fungoides (MF) is a common type of skin cancer that makes it hard to tell harmful T cells from normal ones.
- Researchers used single-cell RNA and T-cell receptor sequencing on skin samples from 12 MF patients, analyzing 18,630 T cells from 9 of them to distinguish between malignant and reactive cells.
- The study found unique gene signatures in malignant T cells that could help differentiate them from reactive T cells, revealing significant variations in cell characteristics among patients.
Article Synopsis
- Hydrochlorothiazide is a common diuretic used to manage conditions like high blood pressure, fluid retention from heart issues, and certain kidney disorders.
- Diuretics increase urine output and can lead to side effects, with major concerns being low blood volume and electrolyte imbalances, alongside rarer issues like skin reactions.
- The case involves an 86-year-old man who experienced lightheadedness and a worsening rash after starting hydrochlorothiazide, prompting an emergency room visit.
Article Synopsis
- - Merkel cell carcinoma (MCC) is an aggressive skin cancer often linked to the Merkel cell polyomavirus, with a rare subtype presenting as combined MCCs featuring an additional tumor component, typically squamous cell carcinoma.
- - This study reports two new cases of combined MCCs with neuroblastic differentiation, characterized by a unique tumor structure involving both a poorly differentiated carcinoma and a neuroblastic component, observed in elderly men with symptoms of isolated inguinal adenopathy.
- - The research utilized various analyses, revealing shared mutations between the tumor components and suggesting that neuroblastic differentiation might occur due to loss of viral protein expression in certain MCC cells, indicating a potential link in their cellular origins.