Development and validation of a predictive model (CHASE-OSA) for preoperative assessment of moderate-to-severe pediatric obstructive sleep apnea.

Purpose: Undetected obstructive sleep apnea (OSA) in children increases the likelihood of perioperative respiratory complications. Current screening tools for OSA often lack sensitivity or are overly complex. This study aimed to develop and validate a simplified preoperative predictive model for moderate-to-severe pediatric OSA.

Comparative evaluation of the upper pharyngeal airway among children with/without UCLP and with/without OSA.

Background: To evaluate the volume and the most constricted cross-sectional area (lumen) sizes of the upper pharyngeal airway among children with/without unilateral cleft lip and palate (UCLP) and with/without obstructive sleep apnea (OSA).

Methods: This prospective study was conducted on 66 Thai children aged 5 to 12 years, encompassing demographic information, polysomnographic data, and sex distribution: 34 with non-syndromic UCLP (16 with OSA; 18 without OSA) and 32 non-cleft children (16 with OSA; 16 without OSA). Subjects were divided into two age groups: preadolescent group (ages 10-12) and younger group (ages 5-9).

Clinical predictors of moderate-to-severe pediatric obstructive sleep apnea.

Background: Children with moderate-to-severe obstructive sleep apnea (OSA) require specific management. However, the risk factors associated with this level of severity in pediatric OSA remain poorly defined. This study aimed to identify clinical predictors of moderate-to-severe pediatric OSA.

An association between heart rate variability and pediatric obstructive sleep apnea.

Background: There are different findings on heart rate variability (HRV) and pediatric obstructive sleep apnea (pOSA) by an overnight HRV or a 1-hr HRV. However, there is limited data of HRV and pOSA diagnosis by using a 24-h HRV test. This study aimed to evaluate if HRV had potential for OSA diagnosis by using a 24-h HRV test.

Dental Anomalies in Ciliopathies: Lessons from Patients with , and Mutations.

Objective: To investigate dental anomalies and the molecular etiology of a patient with Ellis−van Creveld syndrome and two patients with Bardet−Biedl syndrome, two examples of ciliopathies. Patients and Methods: Clinical examination, radiographic evaluation, whole exome sequencing, and Sanger direct sequencing were performed. Results: Patient 1 had Ellis−van Creveld syndrome with delayed dental development or tooth agenesis, and multiple frenula, the feature found only in patients with mutations in ciliary genes.