Publications by authors named "N Somers"
Hydroxyapatite (HA) is known to be the main component of the mineral part of bones. Due to its properties HA is studied for various applications such as bone graft, drug carrier, heterogeneous catalyst or sorbent for waste water treatment. HA can be synthesized or valorized from bone wastes, as the food industry produce billions of kilograms of animal bones.
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- Hepatocellular carcinoma (HCC) is a highly lethal cancer with a low 5-year survival rate, highlighting the need for effective monitoring and prognosis.
- A systematic review analyzed 3,904 studies to investigate if N-glycomics can predict HCC risk and survival in adults with chronic liver disease, ultimately including 30 studies in the analysis.
- The findings suggest that changes in N-glycans, particularly the Mac-2 binding protein glycosylation isomer (M2BPGi), are valuable indicators for predicting HCC development and patient prognosis.
Systematic review: Glycomics as diagnostic markers for hepatocellular carcinoma.
Aliment Pharmacol Ther
January 2024
Article Synopsis
- Hepatocellular carcinoma (HCC) is a serious liver cancer with high mortality; early diagnosis is key to improving treatment options.
- A comprehensive review of scientific literature identified serum N-glycomics, particularly alterations like increased fucosylation and branching, as promising diagnostic markers for HCC, showing strong potential with AUCs between 0.92-0.97.
- More rigorous study designs and larger sample sizes are necessary to validate these findings before N-glycomics can be widely used in clinical settings for HCC diagnosis.
The Genetics service at Guy's hospital has dedicated in-house psychology provision aimed at supporting patients embarking on genetic testing through to coping with the aftermath of genetic diagnoses. This provision offers assessment and intervention within a brief 6-session therapy model and provides a range of therapeutic approaches. Patient satisfaction with the service is high and referral rates have greatly increased over the recent years.
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- Patients with chronic hepatitis C are at risk for serious liver issues, including fibrosis and cancer, even after successful treatment, highlighting the need for ongoing monitoring.
- Researchers analyzed glycomics-based biomarkers in serum samples from 36 HCV patients undergoing antiviral treatment to evaluate the effects on liver inflammation and fibrosis.
- The study found that while all patients achieved sustained viral response, two later developed cancer, and a significant decrease in the GlycoFibroTest suggested liver inflammation improved, though it may not directly indicate reduced fibrosis.