Publications by authors named "N Smeets"
In term neonates with hypoxic-ischemic encephalopathy (HIE), cerebellar injury is becoming more and more acknowledged. Animal studies demonstrated that Purkinje cells (PCs) are especially vulnerable for hypoxic-ischemic injury. In neonates, however, the extent and pattern of PC injury has not been investigated.
View Article and Find Full Text PDFVaginal assisted NOTES hysterectomy in The Netherlands; A prospective cohort study.
Eur J Obstet Gynecol Reprod Biol X
September 2024
Article Synopsis
- This study evaluates the first vaginal assisted Natural Orifice Transluminal Endoscopic Surgery (NOTES) hysterectomies (VANH) in the Netherlands, showcasing its advantages over traditional surgical methods.
- Conducted from August 2019 to April 2023, the study involved 200 patients with benign conditions and recorded key surgical metrics, including average procedure time, blood loss, and complication rates.
- The results indicate that VANH is a safe and feasible option for hysterectomies, but highlights the need for skilled surgeons and thorough patient selection, along with the call for further randomized clinical trials to validate findings.
Objective: To evaluate whether physical function and quality of life was influenced by discharge on the same-day after a total laparoscopic hysterectomy.
Design: Multicentre non-inferiority randomised controlled trial.
Setting: Five teaching hospitals and two university hospitals in the Netherlands.
Background: Early neurorehabilitation can enhance neurocognitive outcomes in very preterm infants (<32 weeks), and conventional magnetic resonance imaging (MRI) is commonly used to assess neonatal brain injury; however, the predictive value for neurodevelopmental delay is limited. Timely predictive quantitative biomarkers are needed to improve early identification and management of infants at risk of neurodevelopmental delay.
Objective: To evaluate the potential of quantitative synthetic MRI measurements at term-equivalent age as predictive biomarkers of neurodevelopmental impairment and establish practical cutoff values to guide clinical decision-making.
Background: Congenital myasthenic syndromes (CMS) are a group of genetic disorders characterized by impaired neuromuscular transmission. CMS typically present at a young age with fatigable muscle weakness, often with an abnormal response after repetitive nerve stimulation (RNS). Pharmacologic treatment can improve symptoms, depending on the underlying defect.
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