Publications by authors named "N Skiba"
Article Synopsis
- Ocular hypertension, a key risk factor for glaucoma, is linked to increased activity and stiffness in the trabecular meshwork (TM) due to cellular interactions.
- Previous research identified high levels of septin-9 in TM cells under hypertensive conditions, prompting studies on its overexpression, deficiency, and drug targeting effects.
- Findings indicate that septin-9 impacts intraocular pressure (IOP) regulation, suggesting that modulating septin cytoskeletal organization could be a potential new treatment strategy for glaucoma.
Article Synopsis
- The transparent ocular lens focuses light onto the retina and its cellular structure is crucial for vision, but the molecular processes behind it are not well understood.
- This study investigates ankyrin-B (AnkB), a protein important for maintaining lens structure and function, using a conditional knockout mouse model.
- Findings reveal that without AnkB, the lens maintains its initial shape but drastically loses clarity, size, and mechanical properties, leading to cataract formation and degradation of key membrane proteins.
Physiological activation of liver X receptor provides protection against ocular inflammation in uveitic glaucoma.
Biochim Biophys Acta Mol Basis Dis
January 2025
Virus-induced trabeculitis is considered a significant cause of uveitic glaucoma, being marked by a sudden increase in intraocular pressure and relatively mild inflammation in the anterior chamber of the eye. In previous proteome analyses of aqueous humor (AH) derived from Cytomegalovirus (CMV) uveitic glaucoma patients, we observed the liver X receptor (LXR) pathway to be among the most prominently activated canonical pathways. In the present study, we explored the role of the LXR pathway in the etiology of glaucoma in association with ocular inflammation.
View Article and Find Full Text PDFThis study illustrates a vital role for ankyrin-B in lens architecture, growth and function through its involvement in membrane protein and spectrin-actin cytoskeletal organization and stability The transparent ocular lens is essential for vision by focusing light onto the retina. Despite recognizing the importance of its unique cellular architecture and mechanical properties, the molecular mechanisms governing these attributes remain elusive. This study aims to elucidate the role of ankyrin-B (AnkB), a membrane scaffolding protein, in lens cytoarchitecture, growth and function using a conditional knockout (cKO) mouse model.
View Article and Find Full Text PDFArticle Synopsis
- Retinal ganglion cells (RGCs) are particularly affected by mitochondrial dysfunction, which is crucial for their distinct somatodendritic and axonal compartments.
- A study was conducted to isolate and compare mitochondrial proteins from these two compartments, revealing unique protein compositions indicative of their different bioenergetic needs.
- The findings suggest that understanding these compartment-specific differences in mitochondrial proteins could lead to therapeutic developments for optic neuropathies.