Publications by authors named "N Siregar"
Functional outcome and histologic analysis of late onset total type brachial plexus injury treated with intercostal nerve transfer to median nerve with local umbilical cord-derived mesenchymal stem cells or secretome injection: a double-blinded, randomized control study.
Eur J Orthop Surg Traumatol
December 2024
Article Synopsis
- This study investigates the effectiveness of intercostal nerve transfer combined with either umbilical cord-derived mesenchymal stem cells (UC-MSC) or secretome therapy in patients with total brachial plexus injury.
- Using a randomized controlled method, the research evaluates pre- and post-operative outcomes in muscle strength, quality of life, and histological assessments in 15 patients over 8 months.
- Results indicate significant functional improvements across both treatment groups, with the UC-MSC group showing better health changes, though no notable differences in histological recovery measures were observed.
COMPARATIVE STUDY OF STRIPED CATFISH SKIN, NILE TILAPIA SKIN, AND PORCINE SKIN AS A XENOGRAFT MATERIAL FOR BURN WOUND.
Ann Burns Fire Disasters
September 2024
Burn injury remains a health problem, specifically in Indonesia. In major burns, xenograft has been proved to be useful as temporary wound coverage. However, some xenografts are not widely available due to cultural, financial and religious backgrounds, or have an unesthetic appearance, such as the scaly appearance of tilapia fish xenograft.
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- Lumbar intrathecal administration is an effective way to deliver drugs directly to the central nervous system, particularly for targeting dorsal root ganglions in chronic pain research using rat models.
- There are two main methods for this administration: chronic catheter implantation, which is more invasive and can induce inflammation, and acute needle puncture, which is less invasive but technically challenging.
- In a study with rat cadavers, ultrasound-guided lumbar intrathecal injections were successful, demonstrating that ultrasound is a valuable tool for improving the accuracy of needle insertion in acute intrathecal procedures.
Introduction: Colorectal cancer has emerged as a concerning health problem, ranking the third most common form of cancer in both men and women. The phosphatase and tensin homologue (PTEN) protein is widely known for its role as an inhibitor of the phosphatidylinositol 3-kinase/protein kinase-B/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway, playing a major role inhibiting tumor development. Previous studies investigated the role of this protein in the PI3K pathway and how it affected colorectal cancer.
View Article and Find Full Text PDF: Preeclampsia has been linked to an inflammatory response that may be brought on by endothelial cell dysfunction. This paper investigates the pathomechanism of syncytiotrophoblast basement membrane (STBM) damage and Placental Protein 13 (PP13) release, which may have a role in systemic endothelial dysfunction in preeclampsia. : This comparative cross-sectional study involves 54 preeclampsia patients (27 early-onset preeclampsia and 27 late-onset preeclampsia) and 27 pregnant women with normal blood pressure.
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