Publications by authors named "N Siragusa"
Aldosterone synthase alleles and cardiovascular phenotype in young adults.
J Hum Hypertens
December 2003
Article Synopsis
- The C(-344)T polymorphism in the CYP11B2 gene, associated with hypertension and cardiac issues, was studied in a young adult population to evaluate its effects on cardiovascular health.
- Among 420 Caucasian students, anthropometric data and cardiovascular measurements were collected, and the genotype was analyzed.
- Results indicated a minor influence of the C(-344) allele on systolic blood pressure in males and interventricular septum thickness in females, suggesting that while the polymorphism has some impact, its significance may vary with age.
Objectives And Design: Angiotensinogen (AGT) gene variants influence angiotensinogen plasma levels in children and young adults. The angiotensinogen promoter (-6)A variant facilitates gene transcription in human tissues and it has been associated with high blood pressure in older adults. A young adult population can be used as a model to study genotype/phenotype associations between AGT (-6) variants and cardiovascular variables.
View Article and Find Full Text PDFObjectives: Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been shown to be an independent risk factor for myocardial infarction and other cardiovascular diseases. The aim of the study was to investigate the relationship between ACE genotype and carotid atherosclerosis evaluated by ultrasonography.
Patients And Methods: ACE I/D polymorphism was determined in 240 low-risk patients (mean age 53.