Publications by authors named "N Sidhu-Malik"
Importance: Cutaneous chronic graft-vs-host disease (cGVHD) is common after allogeneic hematopoietic stem cell transplant and is often associated with poor patient outcomes. A reliable and practical method for assessing disease severity and response to therapy among these patients is urgently needed.
Objective: To evaluate the interrater agreement and reliability of skin-specific and range of motion (ROM) variables of the 2014 National Institutes of Health (NIH) response criteria for cGVHD and a skin sclerosis grading scale (SSG).
Importance: Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States.
Objective: To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma.
Design, Setting, And Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized, double-blind, placebo-controlled trial of topical fluorouracil for chemoprevention of keratinocyte carcinoma.
Article Synopsis
- - A 66-year-old man experienced adult-onset seizures and multiple cerebral cavernous malformations.
- - He developed many eruptive angiokeratomas on his legs, scrotum, abdomen, and back, along with lobular and cavernous hemangiomas on his arms.
- - Genetic testing revealed a mutation in the KRIT1 gene, which is associated with cerebral cavernous malformations (CCM1).
Importance: Topical fluorouracil was demonstrated to be effective in reducing the number of actinic keratoses (AKs) for up to 6 months, but no randomized trials studied its long-term efficacy.
Objective: To evaluate the long-term efficacy of a single course of fluorouracil cream, 5%, for AK treatment.
Design, Setting, And Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) trial was a randomized, double-blinded, placebo-controlled trial with patients from dermatology clinics at 12 VA medical centers recruited from 2009 to 2011 and followed up until 2013.