Analytical and Experimental study of Liquid chromatography-mass spectrometry (LC-MS) profiling of the dehydrated Allium sativum and Allium cepa extracts; a gateway to therapeutic drug development.

Purpose: Practice of medicinal plants for the treatment of various ailments is a history for several decades. Occurrence of active compounds in these plants makes it significant in the era of modern medicine. Garlic and onion a monocotyledonous bulbous flowering plant belonging to the genus Allium has an extensive tradition for being used as anti-inflammatory, anti-cancer, anti-hyperepidemic, anti-diabetic, anti-bacterial, neuroprotective agent against various disorders.

Genotypic and haplotype analysis of Interleukin-6 and -18 gene polymorphisms in association with clinicopathological factors in breast cancer.

Cytokines are multifunctional glycoproteins that play a vital role in the tumor microenvironment and progression of breast cancer. Genetic polymorphisms may influence the immune responses restrained by pro- and anti-inflammatory cytokine expression in tumors. Hence, the present study evaluated the contribution of Interleukin (IL) 6 (rs1800797, rs1800796, and rs1800795) and IL18 (rs1946518, rs187238, and rs549908) genotypes and their haplotypes to the risk, progression of breast cancer in South Indian population.

PCSK9 genetic (rs11591147) and epigenetic (DNA methylation) modifications associated with PCSK9 expression and serum proteins in CAD patients.

Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.

Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study.

Background: Oxidative stress (OS) is a key characteristic feature in cancer initiation and progression. Among multiple cancers, NADPH oxidase (NOX) dependent free radical production is implicated in oxidative stress. P22phox, a subunit of NADPH oxidase encoded by the CYBA gene has functional polymorphisms associated with various complex diseases.