Effects of selenium on the vessel walls and anti-elastin antibodies in spontaneously hypertensive rats.

Selenium (Se) is an exogenous antioxidant that performs its role via expression of selenoproteins. Pathological changes of the structure of the vessel wall, elastin turnover and collagen production may lead to increased stiffness of the vessels with decreased blood flow to the peripheries. The level of anti-elastin antibodies (AEABs) may give information for elastin metabolism.

[A comparative evaluation of the toxic and cumulative properties of the Takal drug group].

The acute oral and dermal toxicity was studied as well as subacute oral toxicity [30 successive days] and skin irritating effect on experimental animals of new drug form "Takal 9", "Takal 14" and "Takal 16" with proved bactericidal and virucidal activity. A complex of toxicometric, unspecific, haematological, biochemical and histological studies were performed. The compositions "Takal 9", "Takal 14" and "Takal 16" are slightly toxic at oral and dermal application.

[An experimental evaluation of the acute and chronic oral toxicity of the antibiotic Bactericin for plant protection].

In relation to the future implementation of the antibiotic bactericin in agriculture are carried out acute, subacute and chronic oral experiments on 128 male white rats and 88 female. In order to determine the parameters of acute oral toxicity, doses (200, 120, 80, 60, 50, 40 mg/kg) of the preparation dissolved in polyethylene glycol are applied. In the subacute--1/10 and 1/20 LD50, and in the chronic (four months)--1/50 and 1/100 LD50.

Toxicological evaluation of agromet (Metalaxyl) preparation.

A complex toxicological study was carried out in relation to the hygienic standardization of the fungicide preparation Ridomil, whose forthcoming production in this country will be under the name Metalaxyl. The study was performed on sexually mature white rats of both sexes, at oral, dermal and inhalation exposure, acute, subacute and chronic experiments, according to the Bulgarian State Standard. Besides the routine toxicological studies were carried also studies for establishing the long-term effects of the preparation (gonadotropic, embryotoxic and teratogenic, cardiovascular).

[The effect of the acetanilide herbicide Acetochlor on the cardiovascular system of white rats].

A study is performed on the long-term effect of the chloracetanilide herbicide "Acetochlor" in doses 21.0; 10.6: 5.