A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules.

An excessive immune response damages organs, yet its molecular mechanism is incompletely understood. Here, we screened a factor mediating organ damage upon genetic activation of the innate immune pathway using Drosophila renal tubules. We found that an antimicrobial peptide, Attacin-D (AttD), causes organ damage upon immune deficiency (Imd) pathway activation in the Malpighian tubules.

Shoe-Type Walking Assist Device with Controllable Subtalar Joint Alignment at Heel Contact.

In this study, we propose a shoe-type walking assist device that can control the inversion/eversion angle of the subtalar joint during heel contact, with the aim of improving the long-term quality of life of both elderly people and young healthy people. The proposed device enables the heel mechanism to rotate dynamically in the frontal plane to lead the subtalar joint alignment to the neutral position when the heel contacts the ground. The effectiveness of the proposed mechanism was demonstrated by comparing the amount of lateral thrust (lateral sway) during stepping movements with and without the mechanism assist in 5 healthy male subjects wearing the device.

Caspase cleaves Drosophila BubR1 to modulate spindle assembly checkpoint function and lifespan of the organism.

Caspases cleave over 1500 substrates in the human proteome in both lethal and non-lethal scenarios. However, reports of the physiological consequences of substrate cleavage are limited. Additionally, the manner in which caspase cleaves only a subset of substrates in the non-lethal scenario remains to be elucidated.

Cardiopulmonary exercise responses in patients with non-ischemic heart failure and a mildly reduced ejection fraction.

The cardiopulmonary response to exercise in patients with heart failure exhibiting a mildly reduced ejection fraction (41% ≤ EF ≤ 49%) remains unclear. A total of 193 consecutive patients with heart failure (excluding those with coronary artery disease) who underwent cardiopulmonary exercise (CPX) tests were examined. CPX variables were compared among patients with reduced, mildly reduced, and preserved EF.