Publications by authors named "N Sharifi"
Article Synopsis
- Diminished ovarian reserve (DOR) leads to a decrease in both the number and quality of eggs, negatively affecting women's fertility and overall quality of life.
- The incidence of DOR is rising, with more younger women being affected, making it essential to identify its causes.
- This study highlights the importance of maternal nutrition—both undernutrition and overnutrition—during pre-conception, pregnancy, and lactation, as it significantly influences the ovarian reserve in daughters developed in the prenatal period.
The CHAARTED study showed that adding docetaxel (Doc) to androgen deprivation therapy (ADT) in men initiating treatment for metastatic hormone-sensitive prostate cancer (mHSPC) prolongs survival, particularly in high-volume disease. Androgens drive both mHSPC and metastatic castration-resistant prostate cancer (mCRPC). Lower nadir serum testosterone concentrations are associated with better outcomes in men treated with ADT for biochemical relapse, while higher androgens at mCRPC are associated with better prognosis and increased benefit from abiraterone.
View Article and Find Full Text PDFBackground: Mentha consumption may associated with blood pressure improvement in humans, but the recent evidence from randomized controlled trials (RCTs) showed inconsistent results. The present study provides a systematic review and meta-analysis of RCTs to investigate the effect of Mentha on blood pressure.
Methods: To cover all relevant literature, a complete search was conducted across PubMed, ISI Web of Science, and SCOPUS databases before March 2024 using PRISMA guidelines.
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common reproductive health issue in women linked to obesity, and this study explores the relationship between diet (measured by the Dietary Obesity Prevention Score or DOS) and PCOS for the first time.
- The study involved 100 women with PCOS and 100 without, measuring their dietary habits, blood markers, and body measurements to assess the impact of DOS on health outcomes.
- Results showed that higher adherence to DOS was associated with lower inflammation levels (CRP) and marginally higher fasting blood sugar, but no significant direct link between DOS and PCOS risk was found.
Article Synopsis
- - Irinotecan is an ineffective standalone treatment for colorectal cancer, but combining it with Metformin and oncolytic Reovirus-infected secretome shows promise in boosting anti-tumor activity.
- - The study analyzed the effects of these combinations on murine colorectal cancer cells (CT26) and demonstrated significantly lower cell viability and higher apoptosis rates with the triple combination over other treatments.
- - Results indicate that using Reovirus-infected secretome alongside Metformin and Irinotecan produces a stronger synergistic effect for inducing cancer cell death compared to other combinations tested.