Publications by authors named "N Serizawa"
Article Synopsis
- - Vitiligo, an autoimmune skin disease causing loss of pigment, was studied in adult Japanese patients to understand the impact of dietary habits on its development, focusing on factors like BMI and nutrient intake compared to healthy controls.
- - The study found that vitiligo patients had a higher BMI and lower consumption of certain nutrients like manganese and vitamin D, with significant correlations between male sex, age, dietary intake, and the severity of vitiligo symptoms.
- - Results suggest managing obesity may help prevent or treat vitiligo, as specific dietary habits were linked to higher disease severity in differing body areas.
Article Synopsis
- Bullous pemphigoid (BP) is an autoimmune skin disease influenced by dietary habits, prompting a study comparing dietary intake between Japanese BP patients and healthy individuals.
- The study found BP patients consumed less vitamin A (retinol) and beverages, and more spices; their disease severity correlated with certain nutrient intakes.
- The researchers suggest that vitamin A supplementation may help prevent or treat BP symptoms due to its notable dietary associations with the disease severity.
Photoreception requires amplification by mammalian rhodopsin through G protein activation, which requires a visual cycle. To achieve this in retinal gene therapy, we incorporated human rhodopsin cytoplasmic loops into rhodopsin, thereby generating and human chimeric rhodopsin (GHCR). In a murine model of inherited retinal degeneration, we induced retinal GHCR expression by intravitreal injection of a recombinant adeno-associated virus vector.
View Article and Find Full Text PDFStarburst amacrine cells amplify optogenetic visual restoration through gap junctions.
Mol Ther Methods Clin Dev
September 2023
Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restoring vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood. There are limits to obtaining efficient gene expression in a specifically targeted cell population by a transgenic approach.
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