A Good check on the Bayes factor.

Bayes factor hypothesis testing provides a powerful framework for assessing the evidence in favor of competing hypotheses. To obtain Bayes factors, statisticians often require advanced, non-standard tools, making it important to confirm that the methodology is computationally sound. This paper seeks to validate Bayes factor calculations by applying two theorems attributed to Alan Turing and Jack Good.

Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification.

Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that bone morphogenetic protein (BMP) signaling is a major driver of this lineage specifying process, but the downstream BMP-dependent transcriptional networks that lead to successful amniogenesis remain to be identified. This is, in part, due to the current lack of a robust and reproducible model system that enables mechanistic investigations exclusively into amniogenesis.

Temporally resolved single cell transcriptomics in a human model of amniogenesis.

Amniogenesis is triggered in a collection of pluripotent epiblast cells as the human embryo implants. To gain insights into the critical but poorly understood transcriptional machinery governing amnion fate determination, we examined the evolving transcriptome of a developing human pluripotent stem cell-derived amnion model at the single cell level. This analysis revealed several continuous amniotic fate progressing states with state-specific markers, which include a previously unrecognized CLDN10 amnion progenitor state.

Normal Ovarian Function in Subfertile Mouse with Cre-Driven Ablation of and .

Insulin receptor signaling promotes cell differentiation, proliferation, and growth which are essential for oocyte maturation, embryo implantation, endometrial decidualization, and placentation. The dysregulation of insulin signaling in women with metabolic syndromes including diabetes exhibits poor pregnancy outcomes that are poorly understood. We utilized the Cre/LoxP system to target the tissue-specific conditional ablation of insulin receptor () and insulin-like growth factor-1 receptor () using an anti-Mullerian hormone receptor 2 () Cre-driver which is active in ovarian granulosa and uterine stromal cells.