Publications by authors named "N Sekar"
1,4-Dialkylamino -5,8-dihydroxy anthraquinones are investigated using density functional theory (DFT) and time-dependent DFT (TD-DFT) for their growth inhibitory potential. The frontier molecular orbital shows that the electron density is located at the anthraquinone core and at the substituents NH and OH in both HOMO as well as in LUMO. The chemical potential and electrophilicity index showed a direct relation, while hardness and hyperhardness had an inverse association with an energy gap.
View Article and Find Full Text PDFSynthesis, photophysical, linear, and non-linear optical properties of 4-methoxyphenyl dicyanovinylene dyes: DFT and TD-DFT studies.
Spectrochim Acta A Mol Biomol Spectrosc
November 2024
Article Synopsis
- Researchers synthesized dyes (MB1-MB5) through Knoevenagel condensation using different chemical precursors and characterized them with various analytical techniques like FT-IR and NMR for structural insights.
- Spectroscopic analyses showed that MB2, MB3, and MB4 had unique properties such as solid-state and aggregation-induced emission, while some dyes (MB1, MB3, MB4) were sensitive to viscosity changes in polar solvents.
- The study highlighted the dyes' acidochromism, solvatochromism, and excellent non-linear optical properties, especially MB1 and MB5, suggesting their potential applications in photonics, bioimaging, and sensor technologies.
Article Synopsis
- The study explores how liquid-liquid phase separation (LLPS) in membrane-less organelles (MLOs) is similar to coacervates, making them useful for understanding life processes.
- A peptide-protein coacervative system was created using poly-L-lysine and intrinsically disordered Pup protein to simulate the electrostatic interactions in MLOs, which could lead to new therapeutic targets.
- The researchers developed a phase diagram for coacervate formation, using turbidity measurements and optical microscopy, while fluorescence microscopy and pH studies highlighted the importance of electrostatics and charge density in this process.
A New Technique for Creation of Femoral Vein Monocusp Neovalve for Patients With Primary Deep Vein Incompetence.
Vasc Endovascular Surg
October 2024
Methods: Monocusp valve was created by folding the vein wall flap so that both sides of the valve will have intimal surface.
Result: Patient had excellent symptomatic improvement. The venous ulcer healed with skin grafting and had not recurred at 30 months follow up.
Background: Neutrophils, the most abundant leukocytes circulating in blood, contribute to host defense and play a significant role in chronic inflammatory disorders. They can release their DNA in the form of extracellular traps (NETs), which serve as scaffolds for capturing bacteria and various blood cells. However, uncontrolled formation of NETs (NETosis) can lead to excessive activation of coagulation pathways and thrombosis.
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