Publications by authors named "N Segata"
Industrialization adversely affects the gut microbiome and predisposes individuals to chronic non-communicable diseases. We tested a microbiome restoration strategy comprising a diet that recapitulated key characteristics of non-industrialized dietary patterns (restore diet) and a bacterium rarely found in industrialized microbiomes (Limosilactobacillus reuteri) in a randomized controlled feeding trial in healthy Canadian adults. The restore diet, despite reducing gut microbiome diversity, enhanced the persistence of L.
View Article and Find Full Text PDFArticle Synopsis
- Interest in how plant-based diets affect the gut microbiome is increasing, but there's limited research on how different diet patterns (omnivore, vegetarian, vegan) impact microbiome profiles across various populations.
- A study involving over 21,000 individuals found that gut microbiome profiles can effectively differentiate between these diet patterns, with a mean accuracy of 85%.
- Key findings show that omnivore microbiomes are heavily influenced by red meat consumption, which is linked to negative health markers, while vegan microbiomes are associated with healthier outcomes and overlap with specific food and soil microbes.
Metagenome-assembled genomes from irradiated human dental plaque.
Microbiol Resour Announc
December 2024
We provide 309 quality-controlled bacterial metagenome-assembled genomes recovered from supragingival plaque metagenomes. Samples were collected from head and neck cancer patients following radiotherapy, so the recovered genomes can be useful to investigate the effects of oral cavity irradiation on oral microbiome members.
View Article and Find Full Text PDFis a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant Gram-negative bacteria. However, the emergence of -acquired FDC-resistant strains highlights the need for advanced tools to identify resistance-associated genomic mutations and address the challenges of FDC susceptibility testing.
View Article and Find Full Text PDFBackground&aims: Celiac disease (CD) and potential CD (pCD) are immune-mediated disorders triggered by the ingestion of gluten. In non-celiac gluten sensitivity (NCGS) neither allergic nor autoimmune mechanisms are involved. Relationships between NCGS and CD need to be further investigated.
View Article and Find Full Text PDF