Publications by authors named "N Seetharamu"
Construction of a risk prediction model for isolated pulmonary nodules 5-15 mm in diameter.
Transl Lung Cancer Res
November 2024
Article Synopsis
- - The study aimed to create a prediction model for assessing the risk of malignancy in solitary pulmonary nodules (SPNs) that are 5-15 mm in size, acknowledging limitations in current detection technologies.
- - A total of 417 patients were analyzed for clinical and imaging features, with key factors like smoking history, nodule characteristics, and specific signs being identified as significant in determining malignancy risks.
- - The developed model showed strong predictive performance, outperforming existing models, with an area under the curve (AUC) of 0.814 for the training cohort and 0.864 for the validation cohort, indicating its high clinical usefulness.
Background: Pulmonary nodules are small, focal lesions often identified via computed tomography (CT) scans. Although the majority are benign, a small percentage of them may be malignant or potentially become malignant, underscoring the importance of early detection and effective management. This study systematically reviews the epidemiology, risk factors, and management strategies for pulmonary nodules, comparing findings across Chinese and non-Chinese populations to better inform the actuarial calculations for predicting the demand of medical services for patients with pulmonary nodules.
View Article and Find Full Text PDFLung cancer is the leading cause of cancer mortality. Despite therapeutic advances in recent years, new treatment strategies are needed to improve outcomes of lung cancer patients. Mutant p53 is prevalent in lung cancers and drives several hallmarks of cancer through a gain-of-function oncogenic program, and often predicts a poorer prognosis.
View Article and Find Full Text PDFRates of Occult Invasive Disease in Patients With Biopsy-Proven Oral Cavity Squamous Cell Carcinoma in Situ.
JAMA Otolaryngol Head Neck Surg
February 2024
Importance: The likelihood that an oral cavity lesion harbors occult invasive disease after biopsy demonstrating carcinoma in situ (CIS) is unknown. While de-escalated treatment strategies may be appealing in the setting of CIS, knowing whether occult invasive disease may be present and its association with survival outcomes would lead to more informed management decisions.
Objective: To evaluate rate of occult invasive disease and clinical outcomes in patients with oral cavity CIS.
Introduction: The underlying factors that contribute to early radiotherapy (RT) termination are understudied, especially in the era of hypofractionated treatment regimens. In this retrospective investigation, we examined the characteristics and causes of premature RT terminations in senior adults (>70 years old) with oral cavity (OC) and laryngeal carcinomas.
Methods: Hundred and eighty-eight patients treated with RT ± systemic therapy for OC and laryngeal cancer from 2017 to 2022 were identified.