Publications by authors named "N Sanjeeva Murthy"
Introduction: A scoring system to characterize the efficacy of middle meningeal artery (MMA) embolization is lacking and would help predict the likelihood of subdural hematoma resolution.
Methods: We developed a simple angiographic classification system ranging from 0 to 3 for quantifying MMA Patency After Coil Embolization (PACE) based residual flow distal to the embolization. MMA embolizations using coils at our institution were used to validate the PACE score system using procedural angiograms.
Advances in acid-degradable and enzyme-cleavable linkers for drug delivery.
Curr Opin Chem Biol
December 2024
Article Synopsis
- Drug delivery vectors enhance the effectiveness of therapies such as small molecules and nucleic acid drugs but face challenges in releasing therapeutic cargo in specific conditions.
- Recent advancements focus on creating acid-degradable and enzyme-cleavable linkages for better performance in endolysosomal release.
- Key innovations include stable azido-acetal linkers, organocatalytic methods for making asymmetric ketals, and linkers activated by enzymes like cathepsin B and β-galactosidase for improved drug delivery.
Immobilization of peptides onto nanofiber dressings holds significant potential for chronic wound treatment. However, it is necessary to understand the adsorptive capacity of the produced substrates and the binding affinity of the peptides to determine the interface success. This study aims at exploring for the first time the influence of electrospun poly(vinyl alcohol)-based nanofibers on the adsorption of a cyclic peptide, Tiger 17, and of a linear peptide, Pexiganan, using quartz crystal microbalance with dissipation monitoring (QCM-D).
View Article and Find Full Text PDFPurpose: To evaluate the myopic and hyperopic defocus delivered to the retina by a dual focus (DF) myopia control contact lens when myopia exceeds 6.00 D.
Methods: Individuals with high myopia were fitted bilaterally with high-powered DF lenses containing power profiles matching a Coopervision MiSight 1 day contact lens (omafilcon A) and a Coopervision Proclear 1 day single vision (SV) lens.