Publications by authors named "N Samanta"
Article Synopsis
- Immune checkpoint inhibitors, a type of cancer treatment, can cause serious side effects, including immune-related myocarditis (irMyocarditis), which can be fatal.
- Researchers studied immune responses in the heart, tumor, and blood of 28 patients with irMyocarditis using advanced techniques like single-cell RNA sequencing and T-cell receptor (TCR) sequencing.
- Their findings showed an increase in certain immune cells in the heart tissue of irMyocarditis patients and identified specific TCR clones associated with severe cases, shedding light on the disease's biology and potential biomarkers.
Article Synopsis
- Cellular stress and aging lead to increased crowding and aggregation of amyloidogenic proteins, prompting researchers to explore the role of crowding in protein aggregation.
- Using a non-protein aggregation sensor called pseudoisocyanine chloride (PIC), the study finds that under cell stress conditions, PIC stabilizes its monomeric form instead of forming aggregates.
- The research concludes that intrinsic crowding is not the main factor driving self-assembly processes during cell stress, which involves various changes in the cytoplasmic environment.
Article Synopsis
- Immune checkpoint inhibitor (ICI) therapy has significantly advanced cancer treatment but is often complicated by immune-related adverse events like checkpoint inhibitor colitis (irColitis).
- A study profiling around 300,000 cells from patients with irColitis uncovered key immune cell expansions and molecular changes in the colon mucosa and blood, highlighting the complexity of the condition.
- Findings indicate that specific T cells and epithelial interactions are crucial for understanding irColitis and may lead to new therapeutic approaches for managing this side effect of ICI therapy.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) can lead to serious immune-related adverse events (irAEs), with ICI-related myocarditis (irMyocarditis) being particularly dangerous and the most lethal among these events.
- Researchers explored immune responses in the heart, tumors, and blood of 28 patients with irMyocarditis compared to 23 controls, using advanced techniques like single-cell RNA sequencing and proteomics.
- Key findings revealed a unique presence of specific immune cells in irMyocarditis heart tissue, distinct T cell responses in heart vs. tumor, and identified novel biomarkers related to fatality that could inform future therapies.
Saccharum ravannae, known as "Ekra" in the Northeast region of India, is an elephant grass species that abundantly grows in the natural habitat of Assam. This study aims to utilize this wild grass species and extract alkaline lignin of high purity through KOH-mediated alkaline hydrothermal pretreatment using the Oil bath process. Lignin recovery was optimized using RSM (response surface methodology) combined with a central composite model.
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