Publications by authors named "N Saleh-Gohari"
Introduction: The apolipoprotein E () genotype has a heterogeneous distribution throughout the world. The present study aimed to characterize the genotype (, ) in healthy individuals compared with Alzheimer cases in Kerman, southeastern Iran, by two standard mutation scanning methods.
Methods: In this case-control study, 90 Alzheimer patients as a case group and 90 healthy individuals as a control group were examined.
Recent genome-wide association studies reported the association of polymorphic alleles of PHACTR1 (rs9349379 (G)), CDDKN2B-AS1 (rs2891168 (G)), COL4A2 (rs11838776 (A)) and SOD2 (rs4880 (T)) with increased risk of coronary artery disease (CAD). The aim of our study was to assess the association of genetic variants with risk of CAD and its severity and in Southeast Iranian population. This study was examined in 250 CAD-suspected patients (mean age 53.
View Article and Find Full Text PDFBackground: Progressive myoclonic epilepsy-4 with or without renal failure (EPM4) is a rare neurological autosomal recessive disorder caused by mutations in SCARB2 gene. In this study, we described clinical features and genetic causes of an Iranian family with two affected individuals whose clinical manifestations closely resembled progressive myoclonus epilepsy.
Methods: Our proband was a 38-year-old male with a history of tremor, generalized seizures, action myoclonus, ataxia, and dysarthria that presumptive diagnosed as progressive myoclonus epilepsy.
Background: -thalassemia is characterized by reduced synthesis of the hemoglobin beta chain that results in microcytic hypochromic anemia and reduced amounts of hemoglobin A (HbA) on hemoglobin analysis. -thalassemias are caused by mutations in the -globin gene, inherited in an autosomal recessive manner. Determining molecular defects in couples carrying -thalassemia is a prerequisite for prenatal diagnosis of the disease.
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- MicroRNAs (miRNAs) are small RNA molecules that help regulate gene expression by binding to specific regions of target mRNAs.
- In a study comparing plasma levels of miR-210-3p and miR-517c-3p between preeclamptic women and healthy controls, it was found that these miRNAs were significantly elevated in preeclampsia cases.
- This research, which is the first to measure miR-517c in preeclampsia using real-time PCR, suggests potential new avenues for understanding the causes of preeclampsia and identifying new biomarkers for the condition.