Publications by authors named "N Sadik"
Background: Many military service members are victims of repetitive blast traumatic brain injuries (rbTBI) and endure diverse altered psychological and behavioural conditions during their lifetime. Some of these conditions include anxiety, post-traumatic stress and pain. Thus, this study attempts to fill the knowledge gap on enduring behavioural and neuroinflammatory marker alterations 1 month after rbTBI.
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- Early Life Adversity (ELA) can lead to increased stress sensitivity in adulthood, particularly affecting females, but the neurobiological mechanisms behind this are not well understood.
- In a study using mice, ELA was shown to decrease serotonin neuron activity and increase stress-related behaviors and hormone levels, while also reducing neurogenesis and increasing inflammation in specific brain regions.
- Targeting serotonin 1A autoreceptors during development appears to prevent the negative impacts of ELA on stress responses and brain function in adult female mice, suggesting potential avenues for intervention.
Article Synopsis
- - The study aimed to assess ocular surface disease (OSD) in children with childhood glaucoma (CG) by comparing 41 eyes from CG patients to 42 eyes from healthy controls.
- - Findings indicated that CG patients had shorter tear break-up time (TBUT) and more severe dry eye disease (DED) symptoms, with higher prevalence of punctate epithelial erosions, particularly influenced by the number of glaucoma medications used.
- - The results highlighted a significant increase in OSD signs and symptoms in CG patients compared to healthy individuals, suggesting the need for further research based on different CG types.
Early Life Adversity (ELA) predisposes to stress hypersensitivity in adulthood, but neurobiological mechanisms that protect from the enduring effects of ELA are poorly understood. Serotonin 1A (5HT ) autoreceptors in the raphé nuclei regulate adult stress vulnerability, but whether 5HT could be targeted to prevent ELA effects on susceptibility to future stressors is unknown. Here, we exposed mice with postnatal knockdown of 5HT autoreceptors to the limited bedding and nesting model of ELA from postnatal day (P)3-10 and tested behavioral, neuroendocrine, neurogenic, and neuroinflammatory responses to an acute swim stress in male and female mice in adolescence (P35) and in adulthood (P56).
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