Symmetries of the vertical ground reaction force, contact time and area, and center of pressure during gait in female patients 3 weeks post-total hip arthroplasty.

Background: Few studies have assessed vertical ground reaction force, contact time, contact area, and center of pressure during gait in the early phase post-total hip arthroplasty. This study aimed to investigate whether these parameters are more pronounced in participants post-total hip arthroplasty compared to healthy controls.

Methods: We included 22 female participants who underwent total hip arthroplasty (age, 68.

Effect of Gold Nanoparticles on the Conformation of Bovine Serum Albumin: Insights from CD Spectroscopic Analysis and Molecular Dynamics Simulations.

With the development of nanotechnology, there is growing interest in using nanoparticles (NPs) for biomedical applications, such as diagnostics, drug delivery, imaging, and nanomedicine. The protein's structural stability plays a pivotal role in its functionality, and any alteration in this structure can have significant implications, including disease progression. Herein, we performed a combined experimental and computational study of the effect of gold NPs with a diameter of 5 nm (5 nm Au-NPs) on the structural stability of bovine serum albumin (BSA) protein in the absence and presence of NaCl salt.

Effect of Acetonitrile on the Conformation of Bovine Serum Albumin.

The use of organic solvents in drug delivery systems (DDSs) either to produce albumin nanoparticles or to manipulate the binding of target molecules to albumin, a promising nanocarrier material, presents challenges due to the conformational changes induced in the protein. In this study, we investigated the alterations in the conformation of bovine serum albumin (BSA) caused by acetonitrile (ACN) in aqueous solution by using a combination of spectroscopic analysis and molecular dynamics (MD) simulations. Ultraviolet (UV) absorption, fluorescence, and infrared (IR) absorption spectroscopy were used to analyze the BSA conformation in the solutions containing 0-60 vol % ACN.

Preparation and Catalytic Properties of Gold Single-Atom and Cluster Catalysts Utilizing Nanoparticulate Mg-Al Layered Double Hydroxides.

Au single atoms and clusters were stabilized on Mg-Al layered double hydroxide nanoparticles (LDH NPs), and the obtained Au@LDH NPs were supported on SiO and CeO. After hydrogen reduction, Au single atoms were found together with Au clusters on LDH/SiO. In contrast to Au single-atom catalysts which are deposited in metal vacancies of oxide supports, the LDH NPs stabilize very small Au species despite the absence of metal vacancies.

Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK-inhibitor-induced tolerant persister cells in ALK-fusion-positive lung cancer.

Cancers can develop resistance to treatment with ALK tyrosine kinase inhibitors (ALK-TKIs) via emergence of a subpopulation of drug-tolerant persister (DTP) cells that can survive initial drug treatment long enough to acquire genetic aberrations. DTP cells are thus a potential therapeutic target. We generated alectinib-induced DTP cells from a patient-derived ALK non-small-cell lung cancer (NSCLC) cell line and screened 3114 agents in the anticancer compounds library (TargetMol).