New Imaging Techniques on the Horizon to Study Overactive and Neurogenic Bladder.

Purpose Of Review: This review will focus on the current usage and the potential future applications of new imaging techniques on the horizon to study overactive and neurogenic bladder.

Recent Findings: Bladder Near-Infrared Spectroscopy (NIRS) has been used to non-invasively identify bladder outlet obstruction, detrusor overactivity, and other forms of voiding dysfunction, but motion artifact has been a limiting factor preventing widespread adaptation. However, newer NIRS units employ accelerometers which enable isolation and splicing of motion and on-going studies show renewed promise for bladder NIRS.

Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species.

Ageing is associated with a range of chronic diseases and has diverse hallmarks. Mitochondrial dysfunction is implicated in ageing, and mouse-models with artificially enhanced mitochondrial DNA mutation rates show accelerated ageing. A scarcely studied aspect of ageing, because it is invisible in aggregate analyses, is the accumulation of somatic mitochondrial DNA mutations which are unique to single cells (cryptic mutations).

A land use regression model to explain the spatial variation of nitrate concentration - A regional scale case study in the north-west of Ireland.

Regional-scale groundwater contamination estimation is crucial for sustainable water management. The primary obstacles in evaluating groundwater include limited data availability, small sample sizes, and difficulties in linking concentration levels to land use patterns. Linear regression identifies the relationship between measured concentrations and both natural and human-influenced factors.

The Case for Baptizing a Dying, Unconscious Atheist.

In the essay "'Please baptize my son': The Case against Baptizing a Dying, Unconscious Atheist," in the same issue of this journal, Tate Shepherd and Michael Redinger describe a case in which a clinical ethicist is consulted when a mother requests that someone from the hospital's spiritual care services baptize her dying, unconscious, atheist adult son. The mother's request produces a moral conflict between providing emotional benefits to the patient's mother from seeing her son baptized at the end of his life and a concern about inflicting dignitary harm on the patient by violating a preference related to a deeply held belief. In this essay, we argue that, in these tragic circumstances, some atheists would be agreeable to being baptized to bring some measure of emotional comfort to their family.