Development and Validation of SI/RS-UHPLC-PDA Method for Olmesartan Medoxomil and Metoprolol Succinate-Related Substance.

Objectives: Olmesartan medoxomil (OLM) and metoprolol succinate (MPS) in fixed-dose combination (FDC) tablet formulation prescribed extensively. Stability indicating (SI) method for impurities and related substance (RS) test quantitates the amount of these analytes in formulation; the manuscript presents SI/RS-ultra-high performance liquid chromatography-photodiode array (UHPLC-PDA) method for OLM and MPS and their impurities.

Materials And Methods: Well-resolved separation of all analytes was achieved with gradient elution on a Shimadzu on Shimpack GIST-C18 (100 mm x 2.

The novel HLA-C*12:365 allele identified in a Gujarati individual from India.

The novel HLA-C allele HLA-C*12:365 identified in an individual from the Gujarati population.

Genomic sequence of the HLA-A*02:01:209 allele identified in a solid organ recipient.

The novel HLA-A allele HLA-A*02:01:209 sequence identified in a solid organ recipient.

Extended genomic sequence of the HLA-DRB1*13:129 allele identified in a donor from the Gujarati population.

The full-length genomic sequence of the HLA-DRB1*13:129 allele was identified in a donor of Gujarati population.

Extended genomic sequence of the HLA-DRB1*14:04:07 and -DRB1*15:53 alleles from Gujarati individuals.

The extended genomic sequences of HLA-DRB1*14:04:07 and -DRB1*15:53 alleles were identified in the Gujarati individuals.