DNA ploidy status as a predictor for malignant transformation in oral leukoplakia: a systematic review and meta-analysis.

Objective: To synthesize literature regarding determination of ploidy status in cases of oral leukoplakia (OL) with the research question: Can DNA ploidy assess malignant transformation (MT) in OL cases?

Study Design: This systematic review was registered in PROSPERO (CRD42022340184). The PECO (Population, Exposure, Comparator, and Outcome) was patients with OL, aneuploidy, diploidy, and MT in OL. Literature search databases included Scopus, PubMed, and Google Scholar.

: AI generation of multiplex immunofluorescence staining from histopathology images.

Hematoxylin and eosin (H&E) is a common and inexpensive histopathology assay. Though widely used and information-rich, it cannot directly inform about specific molecular markers, which require additional experiments to assess. To address this gap, we present a deep-learning framework that computationally imputes the expression and localization of dozens of proteins from H&E images.

Health Care Utilization After a Visit to a Within-Group Family Physician vs a Walk-In Clinic Physician.

Purpose: Primary care access is a key health system metric, but little research has compared models to provide primary care access when one's regular physician is not available. We compared health system use after a visit with a patient's own family physician group (ie, within-group physician who was not the patient's primary physician) vs a visit with a walk-in clinic physician who was not part of the patient's family physician group.

Methods: We conducted a population-based, retrospective cohort study using administrative data from Ontario, Canada, including all individuals formally enrolled with a family physician, from April 1, 2019 to March 31, 2020.

Analyzing Androgen Receptor Expression in Breast Cancer: Insights into Histopathological Parameters and Hormone Receptor Status Among Indian Women.

Breast cancer, an exceptionally hormone-dependent tumor, exhibits a diverse clinical profile. Its therapeutic categorization relies on the expression of key receptors, namely, estrogen receptor (ER), progesterone receptor (PR), and Her2neu. The androgen receptor (AR), a member of the nuclear receptor superfamily, is a biomarker gaining attention in breast cancer research, particularly for triple-negative breast cancers.