Public Health Response Measures for COVID-19 in Kazakhstan.

The article describes measures developed to counter the spread of coronavirus infection in the Republic of Kazakhstan. The first cases of coronavirus disease 2019 (COVID-19) in Kazakhstan were detected on March 13, 2020, among people who arrived from Germany. After declaring the state of emergency in the country, the Ministry of Healthcare of the Republic of Kazakhstan began to formulate and implement a comprehensive package of measures aimed at slowing down and stopping the transmission of infection, preventing outbreaks, ensuring optimal care for all patients, especially the seriously ill, minimizing the negative impact of the pandemic on health systems, social services, and economic activities.

[The assessment of the state of the immune system in the patients presenting with bronchial asthma and concomitant diseases of the nasal cavity and paranasal sinuses].

The objective of the present investigation was to study the influence of diseases of the nasal cavity (NC) and paranasal sinuses (PNS) concomitant with bronchial asthma (BA) on the development of peculiar features of the patients' immune status. Phenotypic characteristics of the main lymphocyte subpopulations from peripheral blood of 101 patients were obtained by means of flow cytometry with the use of fluorescein isocyanate- or phycoerythrin-labeled monoclonal antibodies. Special emphasis was laid on the elucidation of characteristics of humoral and cell-mediated immunity in the patients presenting with BA and concomitant NC and PNS diseases and their comparison with the respective parameters in the patients with isolated lesions in the upper respiratory tract (allergic rhinitis and polypous rhinosinusitis) and lower respiratory tract (bronchial asthma).

[Association of papillomavirus infection and latent hyperprolactinemia in patients with dysplasia and preinvasive cancer of the cervix uteri].

Gynecological screenings carried out in I, 247 females and supplemented by cytological examination of ectoendocervical mucosa smears established significantly higher rates of detection of cytological signs of papillomavirus infection (PVI), regardless of age, in cases of background pathologies of the uterine cervix (10.0%) than in females without detectable pathology of the ectocervix (3.6%).

[Neutrophil chemiluminescence in active cytomegalovirus infection].

The effect of cytomegalovirus infection (CMVI) on the phagocytic activity of leukocytes was studied in patients by the method of luminol-dependent chemiluminescence (CL) used to evaluate the production of oxygen radicals by the peripheral blood neutrophils in phagocytosis of opsonized zymosan (OZ) in 10 female patients with active CMVI and 10 women of the control group. In the patients with CMVI, chemiluminescence in OZ phagocytosis was found to be reduced nearly by 1.5-fold as compared with the controls (pt < 0.