A Scoping Review of Electronic Health Records-Based Screening Algorithms for Familial Hypercholesterolemia.

Background: Familial hypercholesterolemia (FH) is a common genetic disorder that is strongly associated with premature cardiovascular disease. Effective diagnosis and appropriate treatment of FH can reduce cardiovascular disease risk; however, FH is underdiagnosed. Electronic health record (EHR)-based FH screening tools have been previously described to enhance the detection of FH.

The impact of artificial intelligence and machine learning in organ retrieval and transplantation: A comprehensive review.

This narrative review examines the transformative role of Artificial Intelligence (AI) and Machine Learning (ML) in organ retrieval and transplantation. AI and ML technologies enhance donor-recipient matching by integrating and analyzing complex datasets encompassing clinical, genetic, and demographic information, leading to more precise organ allocation and improved transplant success rates. In surgical planning, AI-driven image analysis automates organ segmentation, identifies critical anatomical features, and predicts surgical outcomes, aiding pre-operative planning and reducing intraoperative risks.

Phenotypic and Genetic Heterogeneity of a Pakistani Cohort of 15 Consanguineous Families Segregating Variants in Leber Congenital Amaurosis-Associated Genes.

Background: Leber congenital amaurosis (LCA) is a congenital onset severe form of inherited retinal dystrophy (IRD) and a common cause of pediatric blindness. Disease-causing variants in at least 14 genes are reported to predispose LCA phenotype. LCA is inherited as an autosomal recessive disease.

Non-consumptive value of hilsa fishery restoration in West Bengal, India: An application of contingent valuation method.

The study focuses on the socio-cultural importance of hilsa fishery in West Bengal, which extends beyond mere sustenance, symbolising heritage, identity, and community spirit, particularly in South 24 Parganas district. As the state fish and a crucial livelihood source for many fishers, grave concerns have recently been flagged due to reduced catches and increased prices, highlighting the need for restoration. This study seeks to measure the non-consumptive value of hilsa fishery by involving 200 participants, 100 fishers and 100 consumers, utilising the Contingent Valuation Method (CVM) with a payment card.

Ferrotoroidicity in CsFeCl·DO.

The promise of antiferromagnetic spintronics largely relies on the possibilities of electrical manipulation of antiferromagnetic states, which requires the exploration of innovative material platforms to meet the challenge. Erythrosiderite-type compounds constitute a class of non-oxide materials presenting magneto-electric couplings ranging from multiferroicity to linear magneto-electric behaviour. In this communication, we demonstrate that Cs[FeCl(DO)] shows evidence of another ferroic order, ferrotoroidicity, providing an alternative way of manipulating the magnetic states.