Functional changes of macrophages induced by dimeric glycosaminylmuramyl pentapeptide.

Under the influence of dimeric glucosaminylmuramyl pentapeptide (diGMPP), a component of bacterial cell wall, macrophages undergo certain changes similar to those associated with dendritic cell (DC) maturation. The effect of diGMPP on DCs resulted in maturation and expression of CD83. Macrophages treated with diGMPP displayed reduced phagocytic activity and elevated ability to kill ingested bacteria.

[Evaluation of serum bactericidal activity by laser flow cytofluorometry].

A method for evaluation of serum bactericidal activity against S. aureus by laser flow cytofluorometry has been developed and proposed for clinical application. This method was used to study the overall bactericidal activity of donors' sera and to estimate the contribution of complement to the process of bacteriolysis.