Number of correlates of membrane metabolism and long-term potentiation in rat brain slices.

Long-term potentiation was elicited in living slices of rat olfactory cortex by stimulation of the lateral olfactory tract. A group of interdependent parameters of membrane metabolism was studied, i.e.

Peroxidative oxidation of lipids in slices of olfactory cortex of the rat brain during long-term potentiation.

The content of the products of the peroxidative oxidation of lipids (POL) in slices of olfactory cortex of the rat brain during long-term potentiation was investigated. The phasic character of the changes in the level of POL as a function of the duration of potentiation was demonstrated. The initial stages of potentiation (5 min) is characterized by an increase in POL; the stationary phase (15 min) is accompanied by inhibition of free-radical oxidation of lipids; the concluding phase of long-term potentiation (30 min) leads to the normalization of POL.

[Lipid peroxidation in slices of rat olfactory cortex under long-term potentiation].

Long-term potentiation (LTP) was shown to be accompanied by an increase in the lipid peroxidation at the initial stage. Stationary phase resulted in inhibition of the free radical lipid peroxidation. A decline of the LTP is accompanied by normalising of the lipid peroxidation level.

[Lipid peroxidation in the rat brain under neurotization conditions].

Neurotization provoked a stable activation of lipid peroxidation in homogenates and synaptosomes of the rat brain cortex. The activation persisted for 8 days after cessation of the neurotization. A single short-term emotional-pain stress produced but a transient increase of the lipid peroxidation level.

[Rat brain lipid peroxidation system under conditions of emotional-pain stress of varying duration].

Neurotization of rats, developed after long-term emotional-painful stress, resulted in activation of lipid peroxidation in brain both within 2 days and 8 days of stress interruption. Compensative activation of the antioxidative protective system in response to increase in lipid peroxidation rate was not observed especially in synaptosomes. Activation of glutathione peroxidase, which is involved in adaptation, was accompanied by inhibition of superoxide dismutase and glutathione transferase.