[Homoarginine level and methionine-homocysteine balance in patients with ischemic heart disease.].

The level of homoarginine (hArg) in terms of prognostic significance may exceed the natriuretic peptides and other well-known markers according to the latest data about the progression of cardiovascular diseases. The lack of data on the association of hArg levels with levels of other metabolites makes it difficult to understand its role in the pathogenesis of cardiovascular diseases. Relationships of hArg and other amino acids, including methionine (Met) and total homocysteine (tHcy), and their ratio in patients with ischemic heart disease were evaluated.

[The level of circulating humanin in patients with ischemic heart disease.].

At present, great interest is caused with evaluation of new markers in blood circulation for the estimation a tissue oxidative metabolism disturbance due to the presence of secondary mitochondrial dysfunction in patients with coronary heart disease. Сoronary heart disease is generally accompanied with a decline in mitochondrial respiration and represents the root cause of metabolic abnormalities in tissues. To gain insight into rate of decline of mitochondrial oxidative metabolism in tissues there were proposed humanin as a new marker.

[The value of detection of homoarginin level in patients with ischemic heart disease under operations of myocardium re-vascularization.].

The homoarginine is proposed as a prognostic metabolic criterion of danger of stroke and myocardium infarction and evaluated in this capacity in a number of population studies. The actual study analyzed content of this cardio-metabolic marker and main amino acids in blood plasma of 59 patients (46 males and 13 females, aged 61,4 ± 6,2 years) wit6h ischemic heart disease send to planned operation of aortocoronary bypass surgery and also 30 healthy individuals aged 50,4 ± 9,2 years. The concentration of homoarginine and amino acids was detected using high-performance liquid chromatography with identification of ortho-phthalic derivative with fluorometric detecting using genuine developed technique.

[The efficacy of prevention of postoperative cognitive dysfunction in cardiac surgeries with the use of the cerebrolysin].

Aim: To assess the efficacy of postoperative cytoprotection with cerebrolysin in cardiac surgeries without using cardiopulmonary bypass and to analyze the changes in the blood circulation in the postoperative period in groups with- and without cerebrolysin preconditioning.

Material And Methods: Thirty-eight patients, who underwent coronary and mammaro-coronary bypass grafting without using cardiopulmonary bypass, were included in the study. Fifteen patients received cerebrolysin before surgery.