Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to reinstate tolerance in RA. Using single-cell and spatial transcriptomics of ST biopsies, as well as co-culture systems, we identified condition- and niche-specific DC clusters with distinct functions.
View Article and Find Full Text PDFPurpose: To understand good care from the perspective of hospitalised older persons.
Background: Older persons are the largest group of hospital users, and numbers will increase in the next decades. Hospital organisations are attempting to transform traditional care models to meet the specialised needs of hospitalised older persons.
This network meta-analysis of 13 randomized trials comparing injection treatments for trapeziometacarpal joint arthritis found no robust evidence for any treatment. There is low-quality evidence that corticosteroid and hyaluronic acid injections are superior to placebo for mid-term pain.
View Article and Find Full Text PDF