Pharmacist-Mediated Deprescribing in Long-Term Care Facilities: A Systematic Review.

Multimorbidity and polypharmacy are prevalent among Long-Term Care (LTC) users. Older people, who most use LTC services, are more prone to drug-related problems, which polypharmacy aggravates. Deprescribing is a key intervention to address polypharmacy and inappropriate medication.

Sarc-Global: a new sarcopenia screening tool in older adults.

Background: Sarcopenia is associated with clinical complications that increase mortality in older adults. Current screening tools, such as Sarc-F and Sarc-CalF, focus primarily on muscular performance but have limited sensitivity in identifying elderly individuals at risk of sarcopenia. The present study aims to develop a more comprehensive sarcopenia risk screening tool, Sarc-Global, which integrates additional anthropometric and clinical variables to enhance the sensitivity and accuracy of sarcopenia risk assessment in older adults.

The Hunga Tonga-Hunga Ha'apai volcanic barometric pressure pulse and meteotsunami travel recorded in several Antarctic stations.

The Hunga Tonga-Hunga/Hunga-Ha'apai eruption on January 15, 2022 sent off a plume of ash material up to the stratosphere and triggered a meteotsunami and barometric pressure pulse that rippled through the atmosphere and oceans all around the world. The nature of the volcanic event and its global impacts on the oceans, atmosphere, lithosphere and the cryosphere are a matter of debate. Here we present a first overview of the time travel of the sound atmospheric pressure wave through the Antarctic continent based on in situ measurements, which represented a unique event observed through the polar ice sheet during the instrumental meteorological era.

Captopril inhibits the overproduction of proopiomelanocortin and adrenocorticotropic hormone in the pituitary gland of male diabetic mice in close relationship with an increase in glucocorticoid receptor expression.

Prior investigation shows that diabetic patients present hypothalamus-pituitary-adrenal (HPA) axis hyperactivity related to impaired negative feedback. This study investigates the effect of Captopril on the overproduction of adrenocorticotropic hormone (ACTH) and its precursor proopiomelanocortin (POMC) in the pituitary gland of male diabetic mice. Diabetes was induced by intravenous injection of alloxan into fasted Swiss-webster mice, and the animals were treated with Captopril for 14 consecutive days, starting 7 days post-diabetes induction.