Publications by authors named "N S Kulkarni"
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome-wide association study (GWAS) efforts for childhood obesity revealed 19 independent signals for the trait; however, the mechanism of action of these loci remains to be elucidated. To molecularly characterize these childhood obesity loci, we sought to determine the underlying causal variants and the corresponding effector genes within diverse cellular contexts.
View Article and Find Full Text PDFIntroduction: Mortality and morbidity in persons with haemophilia (PWH) have decreased due to improved diagnosis and treatment along with comprehensive population outreach efforts, but the impact is not uniform in different countries.
Aim: The study aims to assess all-cause and intracranial haemorrhage (ICH)-specific mortality of PWH in India.
Methods: This is a retrospective, observational, multi-centric cohort study of 1020 haemophilia patients from three centres in India.
Article Synopsis
- Cancer-associated fibroblasts (CAFs) are crucial for tumor growth and immune suppression, with their behavior varying significantly between 2D and 3D culture conditions.
- In 2D cultures, CAFs adopt a myofibroblast subtype, while in 3D spheroid models, they become more inflammatory and support cancer cell growth, leading to protective effects against natural killer (NK) cell attacks.
- This study highlights the importance of 3D models for understanding CAF functionality and suggests that these models can improve drug discovery efforts by mimicking the more clinically relevant tumor microenvironment.
Article Synopsis
- The study focuses on malignant pleural mesothelioma (MPM), a serious lung cancer, and investigates a new method to deliver the chemotherapy drug Doxorubicin using a specially developed hydrogel, aiming to improve treatment efficacy.
- The hydrogel, which combines GelMa and acrylamide, shows promising physical properties such as quick gelling, high swelling, and easy injectability, while effectively releasing Dox over 12 days without compromising its effectiveness.
- In cell studies, the Dox-loaded hydrogels outperform plain Dox in reducing tumor growth, demonstrating significant potential for localized chemotherapy in treating MPM.