[EPR study of the influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats].

The influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats has been studied by electron paramagnetic resonance. It was found that nitric oxide synthesis in Krushinskii-Molodkina rats is increased compared with that in Wistar rats. A significant enhancement of the EPR signal of Hb-NO complexes in the animal blood was observed after hypoxia simulating the altitude of 5000 m above the sea level, in particular in the presence of sodium nitrite and the NO-synthase inhibitor L-nitroarginine.

[Morpho-functional interactions of the iris peripheral nervous fibers with the neurons developing in the rat anterior eye chamber].

The intraocular grafts of the septal or hippocampal embryonic tissues developing in the rat anterior eye chamber for three to four months were investigated by electron microscopy. The aim of this study was both the ultrastructural identification of the peripheral nervous fibers entering the grafts from host iris and the estimation of their capacity to establish true synaptic contacts with the central nervous system neurons of the grafts. The bundles of myelinated and unmyelinated axons, surrounded by the Schwann cell cytoplasm, were observed within the perivascular spaces of the ingrowing blood vessels.

[A comparative study of antistroke activity of the new drug "cerebral" and its fractions in rats].

The effect of the new drug "cerebral" and its fractions 1-3 on the model of bilateral hemorrhagic stroke in white rats was studied with reference to the action of cebrolysin and cerebrolysate-M. With respect to the general functional state, behavioral activity restoration, and morphological data, the most pronounced antistroke action was observed for the cerebral-1 fraction. This fraction was further separated into three subfractions.

[The general physiological mechanisms of glutamate influence on the central nervous system].

The L-Glutamate, is dicarboxilic amino acid which plays the important role in maintenance of normal functioning of the central nervous system (CNS) in invertebrate and vertebrate animals. It carrying out functions of amphibolic intermediate in biosynthesis and degradation of amino acids and some nitrogenous substances. Besides, L-Glutamate acid possesses a significant role in the regulation of the bioenergetics processes that proceeding in nervous system, due to direct or indirect participations in the reactions of glycolysis, gluconeogenesis, synthesis of ketone bodies and formation of glycogen.

[Structural basis of the intracortical synchronization of epileptic potentials in the sensomotor region of the rat neocortex].

In control rats, penicillin-induced epileptiform discharges were completely synchronous in the neocortex sites at a distance of up to 4 mm from each other. Number of the cells decreased by 45.5% during 90 days in isolated cortical slabs and the synchronisation disappeared.