Publications by authors named "N S Knelange"
Article Synopsis
- - The study assessed COVID-19 mortality rates among patients receiving Chimeric Antigen Receptor (CAR) T-cell therapy for blood cancers, comparing outcomes across three years (2020, 2021, 2022) during the Omicron period.
- - There was a significant decline in COVID-19-related mortality: from 43.6% in 2020 to 7.5% in 2022, indicating improvement over time, with year of infection identified as a key predictor of survival.
- - Although mortality decreased, CAR T-cell recipients still face a higher risk of complications compared to the general population, highlighting the need for ongoing monitoring and preventive measures during their treatment.
The objective of the study was the analysis of clinical types, outcomes, and risk factors associated with the outcome of adenovirus (ADV) infection, in children and adults after allo-HCT. A total number of 2529 patients (43.9% children; 56.
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- Nocardiosis is a serious infection that can occur after hematopoietic cell transplantation (HCT), and this study aimed to identify its risk factors and the impact of certain preventive treatments.
- A review of 64 cases of nocardiosis and 128 matched controls showed that factors like tacrolimus use, low lymphocyte counts, male sex, recent corticosteroid use, and previous CMV infections increased the risk of developing this infection.
- Conversely, patients on trimethoprim-sulfamethoxazole prophylaxis had a significantly lower risk of nocardiosis; however, those who did develop it had poorer survival rates compared to controls.
Article Synopsis
- * A study involving 1439 acute leukemia patients showed that 6% had a prior history of IA before receiving alloSCT, resulting in higher non-relapse mortality (17.3% for those with IA compared to 11.2% for those without), and poorer outcomes in terms of relapse-free and overall survival rates.
- * Despite the challenges linked to pre-SCT IA, over two-thirds of patients with this condition were alive one
Pneumocystis pneumonia (PCP) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). However, allo-HCT procedures have evolved toward older patients, unrelated donors, and reduced-intensity conditioning, possibly modifying the risks. Polymerase chain reaction (PCR), widely used nowadays, is more sensitive than microscopy diagnostic methods.
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