Social determinants of health inequalities in early phase clinical trials in Northern England.

Background: Early phase clinical trials in Oncology represent a subspecialised area where UK patient selection is influenced by access to Experimental Cancer Medicine Centres (ECMCs). Equity of access with respect to social determinants of health (SDoH) were explored for two major ECMCs.

Methods: A retrospective cohort study including all referrals to Newcastle and Manchester ECMCs in 2021 was completed.

Dataset of spectroscopic, crystallography and DFT of novel 1,2-bis[-6-(4-pyridylmethylamido)pyridyl-2-carboxyamido]butane.

This paper provided the dataset obtained from spectroscopic, crystallography and DFT of a new compound namely 1,2-bis[-6-(4-pyridylmethylamido)pyridyl-2-carboxyamido]butane. This compound is prepared from the reaction between -6-[(4-pyridylmethylamino)carbonyl]-pyridine-2-carboxylic acid methyl ester with butane-1,4-diamine. The preparation of this compound is modified from the method described in our article [1].

Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders.

Purpose: Tumour genomic profiling is of increasing importance in early phase trials to match patients to targeted therapeutics. Mutations vary by demographic group; however, regional differences are not characterised. This was investigated by comparing mutation prevalence for common cancers presenting to Newcastle Experimental Cancer Medicine Centre (ECMC) to The Cancer Genome Atlas (TCGA) and utility of trial matching modalities.

Disaster risk index on disaster management budgeting: Indonesia's national data set.

Unlabelled: This study analysed Indonesian local government budgeting model based on the Disaster Risk Index (DRI). This study used a sample of local governments in Indonesia consisting of provincial, regency and municipality levels, especially for 2015-2019 data with a final sample of 2609 observations. The results of the analysis and testing showed that most of the Indonesian local governments fall into the high category in the DRI.