Efficacy and Safety of Andexanet Alfa Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta-Analysis.

Factor Xa inhibitors (FXaI) are increasingly used for anticoagulation therapy, yet their association with intracranial hemorrhage poses a significant challenge. Although andexanet alfa (AA) and four-factor prothrombin complex concentrate (4F-PCC) have shown promise in reversing FXaI effects, their comparative efficacy and safety remain uncertain. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a literature search on electronic databases to obtain the relevant studies until May 16, 2024.

Profiling of two species using LC-ESI/MS with evidence of their hepatoprotective activity.

and are only reported to have significant cytotoxic activity against certain cancer cell lines with phytochemical investigation of their petroleum ether and the ethyl acetate extracts. Further investigation was suggested concerning their hepatoprotective activity and relating it to the metabolic profile of their defatted methanol extracts using LC-ESI/MS analysis. Hepatoprotective activity was evaluated through assessment of three liver parameters as well as liver histopathological examination in thioacetamide-induced hepatotoxicity model.

Structural characterization of three cytotoxic steroidal saponins from the leaves of Agave desmetiana hort.

Three steroidal saponins detected by LC-MS were isolated from the leaves of Agave desmetiana hort. The three saponins were characterized as; Tigogenin 3 - [{O - β - D - xylopyranosyl (1 → 2) - α - L-rhamnopyranosyl (1 → 3)}-β-D- glucopyranoside), Tigogenin- 3 - ([O- α -L-rhamnopyranosyl (1 → 3) - β - D - glalactopyranosyl (1 → 2)] - β - D - glucopyranoside) and Tigogenin- 3 - ([{O - α - L - rhamnopyranosyl (1 → 4)} - β - D - galactopyranosyl (1 → 3) - β - D - xylopyranosyl (1 → 2)] - β - D - glucopyranoside). Identification and structure elucidation of the isolates were done via 1D and 2D NMR techniques, and chemical methods.

Phytochemical investigation of and family Aizoaceae and evaluation of their cytotoxic activity.

This study aims to shed light on the phytochemical composition and the biological effect of two members of family and Gas chromatography coupled to mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) was used to investigate the lipoidal matter and the phenolic content, respectively. The MTT assay was used to evaluate the cytotoxic activity against MCF-7 (breast cancer), HepG2 (liver cancer) and HCT-116 (colorectal cancer) cell lines. The total phenolic acids and the total flavonoid content of were found to be higher than that of Phytol, hexadecanoic acid, -coumaric, ferulic and - hydroxybenzoic acids were the major detected compounds.

Production of Terretonin N and Butyrolactone I by Thermophilic TM8 Promoted Apoptosis and Cell Death in Human Prostate and Ovarian Cancer Cells.

The anticancer activity of terretonin N () and butyrolactone I (), obtained from the thermophilic fungus TM8, was intensively studied against prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines. According to this study, both compounds showed potent cytotoxicity towards ovarian adenocarcinoma cells (SKOV3) with IC 1.2 and 0.