Publications by authors named "N S Elias"
Background/aim: Predictors of recurrence following resection of hepatocellular carcinoma (HCC) are not fully established. This study investigated potential risk factors and prognostic scores for this situation.
Patients And Methods: In 297 patients undergoing resection of HCC between 2000 and 2021, risk scores and potential additional risk factors for intrahepatic and extrahepatic recurrence were assessed.
Adaptive introgression involves the acquisition of advantageous genetic variants through hybridisation, which are subsequently favoured by natural selection due to their association with beneficial traits. Here, we analysed speciation patterns of the kleptoparasitic spider, Argyrodes lanyuensis, through genomic analyses and tested for possible genetic evidence of adaptive introgression at the Taiwan-Philippines transition zone. Our study used highly polymorphic SNPs to demonstrate that speciation occurred when the Hualien (on Taiwan Island + Green Island) and Orchid Island + Philippine lineages separated during the early to mid-Pleistocene.
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- The study investigates the readiness to adopt healthy lifestyle changes in patients who have undergone kidney and liver transplants, focusing on both physical and mental preparedness for a weight-loss program.
- Twelve kidney and twelve liver transplant patients participated in the program, which included a year-long usage of fitness devices and group sessions on lifestyle modifications.
- Results showed that most participants demonstrated strong physical readiness, with notable weight loss observed in nearly half of them, and higher mental readiness was linked to greater weight loss achievements.
Article Synopsis
- Kidney transplantation from HIV-positive donors to HIV-positive recipients is a growing practice, initiated under a 2016 U.S. law, and is currently being evaluated for broader clinical implementation.
- An observational study involving 408 candidates at 26 U.S. centers assessed the safety and health outcomes of kidney transplants from both HIV-positive and HIV-negative donors to HIV-positive recipients, finding no significant difference in major health risks between the two donor groups.
- Results indicated similar long-term survival rates, graft success, and complication rates across both groups, although recipients of kidneys from HIV-positive donors showed a higher incidence of HIV breakthrough infections.
Article Synopsis
- - In vitro studies show that kidney transplants from gene-edited pigs may face more challenges in nonhuman primates (NHPs) than in humans, but pig-to-human transplants have distinct advantages like better communication with the surgical team and improved monitoring methods.
- - Advantages for recipients of xenotransplants include better clinical-grade microbiological management, access to advanced monitoring and imaging techniques, and available therapeutic interventions not easily accessible in NHP models.
- - To expedite safe human clinical trials, it's proposed to start small pilot cases for high-risk patients, particularly those over 60, with specific blood types, or diabetic nephropathy, as many patients on the kidney waitlist die each year due to lack of alternatives.