The biochemical bone formation marker aminoterminal type 1 procollagen propeptide (total P1NP) was determined in 91 serum samples from healthy male donors aged 19 to 60 years, by using an "Elecsys Total P1NP" kit of reagents ("Roche-Diagnostics", Germany) on an "Elecsys 2010" electric chemiluminescence analyzer ("Roche-Hitachi", Japan). A relationship was found between the serum concentration of total P1NP and the age of the examined males. At the age of 19-20 years, the content of the propeptide is highest, at the age of 21-24 years, it decreased by 1.
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