Publications by authors named "N S Bogdanova"
Background: The 313-variant polygenic risk score (PRS) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS across different European populations which could influence risk estimation has not been performed.
Methods: We explored the distribution of PRS across European populations using genotype data from 94,072 females without breast cancer diagnosis, of European-ancestry from 21 countries participating in the Breast Cancer Association Consortium (BCAC) and 223,316 females without breast cancer diagnosis from the UK Biobank.
Article Synopsis
- * Results show that offspring of intoxicated fathers have significantly reduced motor activity and altered anxiety-like and depressive-like behaviors.
- * The findings suggest that alcohol consumption by males may affect gene methylation in offspring, leading to changes in enzyme activity and neuropeptide balance that influence behavior.
: Placental cadherin (CDH3) is an adhesion molecule expressed in many malignant tumors. The role of serum CDH3 in atherosclerosis is unclear. : This 3-year follow-up study measured atherosclerosis and serum CDH3 in 218 angiography inpatients.
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- * A study involving 342 endometrial cancer patients and 178 breast cancer patients from Almaty, Kazakhstan found 2.9% of endometrial cases carried pathogenic MMR variants, while 4.1% had HDR variants.
- * In the breast cancer group, 4.5% had MMR variants and 6.7% had HDR variants, indicating that these gene variants are common in both types of cancer within the Kazakh population.
Article Synopsis
- Clinical genetic testing helps find cancer risks by identifying gene changes, but some of these changes are confusing because we don't know what they mean (called VUS).
- Researchers studied a huge number of breast cancer patients and healthy people to understand these confusing gene changes better.
- They found that their method of analyzing data closely matches what other experts say about which gene changes are harmless or harmful, giving more information about 785 unclear changes.