[The reaction of the immune system to insulinlike growth factor-1 in postmenopausal women with breast cancer].

Taking into account the information about the role of insulin-like growth factor -1 (IGF-1) in breast cancer the main aim of the present study was to investigate the cellular immune response to IGF-1. There were examined 58 patients with breast cancer (61 +/- 1 years, BMI 31,2 +/- 0,9 kg/m2, all postmenopausal) and 10 with benign tumors of the breast (56 +/- 2 years, BMI 30,8 +/- 0,7 kg/m2 all menopausal) as well as 17 patients suffering from cancer of different sites. Sensibilization of lymphocytes to IGF-1 was measured in the reaction of blast transformation of peripheral blood lymphocytes.

[Immunologic predictors of diabetes mellitus in menopausal breast cancer patients].

Although the relations between diabetes mellitus (DM) and breast cancer (BC) are lately widely discussed, the actual causes for cancer predisposition in patients with diabetes are currently unclear. This study was designed to define the frequency of DM immunological predictors occurrence and immune system function shifts in patients with breast cancer. Sixty four BC patients, 19 patients with benign breast conditions and 40 healthy individuals were included.

[Lymphocytic sensitization to insulin as a risk factor of diabetes mellitus].

Aim: to search for immunological risk factors of diabetes and prediabetes.

Subjects And Methods: The prospective study included 91 patients (26 males and 65 females; mean age 45.9 years; body mass index 27 +/- 3 kg/m2).

[Sensitization of lymphocytes to insulin as one of risk factors of ischemic heart disease].

Prevalence and character of sensitization of lymphocytes to insulin and its prognostic significance were studied in 71 patients with ischemic heart disease and 55 healthy people. Direct overt sensitization of lymphocytes to insulin was found in 14 of 71 patients (p<0.01 compared with control group).

[Lymphocytes sensitization to insulin in acute ischemic attacks].

The study aimed at investigation of frequency and character of lymphocyte sensitization to insulin in patients with acute disturbances of brain blood circulation (ADBBC). Fifty patients with ADBBC (38-with ischemic stroke, 5-with hemorrhagic stroke, 7-with transient ischemic attacks), 17 patients with cerebrovascular diseases (CVD) and 20 age- and sex-matched controls have been studied. Lymphocyte sensitization to insulin (LS) was revealed in 32 patients with stroke and in 5-with CVD.