EARLY POSTNATAL DYSFUNCTIONING OF THE BRAIN MUSCARINIC CHOLINERGIC SYSTEM AND THE DISORDERS OF FEAR-MOTIVATED LEARNING AND MEMORY.

The aim of the study was to investigate the early postnatal dysfunctioning of the brain muscarinic cholinergic system as a major factor in the development of cognitive disorders similar with somewhat is noted in animal models of depression and in patients with Major Depressive Disease. The present study examined the processes of learning and long-term retention of information obtained in the two important tasks of non-declarative memory - active avoidance, motivated by foot shock-induced fear, and the elevated plus-maze, based on the natural fear.Experiments were carried out on male white wild rats (n=60).

CHARACTER OF THE CHANGES IN FEAR MOTIVATED DECLARATIVE MEMORY IN THE HIGH IMMOBILIZATION "DEPRESSIVE" RATS.

Present study investigated possible differences in the learning and memory of declarative memory task in rats selected according to the differences in immobilization response that is in high immobilization "depressive" and low immobilization "non-depressive" rats. Understanding the character of learning and memory disturbances in basal conditions of animal models of depression is still very topical for more intimate definition of the pathophysiology of major depressive disorder and appropriate searching the ways of its correction. Experiments were carried out on the adult white wild rats (with the weight 200-250 g, n=20).