Publications by authors named "N Rochow"
Article Synopsis
- Medical devices that contact blood can cause clotting and other complications, which is typically managed using anticoagulants and antiplatelet agents, though these can increase bleeding risks.
- A new method investigates coating polydimethylsiloxane (PDMS) surfaces with an antithrombin-heparin complex and tissue plasminogen activator to inhibit clotting and dissolve early clots.
- Different coating processes were tested, and the results showed that a specific sequential application of these agents improved their effectiveness and stability, suggesting potential for better blood compatibility in medical devices.
Article Synopsis
- Preterm infants tolerate intravenous (IV) fat less well than enteral feeding, leading to issues like hypertriglyceridemia, so it's recommended to limit parenteral fat intake to 3.5-4.0 g/kg/d compared to 8 g/kg/d from human milk.
- The study examined fatty acid profiles in preterm infants using gas chromatography/mass spectrometry, comparing breast milk and lipid emulsions, and looking at differences based on triglyceride levels.
- Results showed that plasma fatty acid levels differed significantly from breast milk and lipid emulsions, with hypertriglyceridemic infants having higher levels of certain fatty acids, suggesting the need for careful formulation of lipid solutions for these infants.
Body composition assessments using air displacement plethysmography (ADP, PEAPOD) have been introduced into clinical practice at a few neonatal units. To allow accurate body composition assessments in term and preterm infants, a workflow for routine testing is needed. The aim of this study was to analyze the feasibility of weekly routine ADP testing.
View Article and Find Full Text PDFType 1 Diabetes Mellitus in the First Years of Life - Onset, Initial Treatment, and Early Disease Course.
Exp Clin Endocrinol Diabetes
August 2024
Objective: This study investigated the onset and the choice of treatment in children with very early onset of type 1 diabetes mellitus (T1D).
Methods: The study included 5,763 patients from the German Diabetes Patient Follow-up registry with onset of T1D in the first 4 years of life from January 2010 - June 2022. The analysis included diabetes-specific parameters, anthropometric data, and mode of treatment at onset, within the first and second year of T1D.
The quality-initiative analysis of weekly duplicate PEAPOD body composition measurements was conducted from clinical practice (January to September 2021) on preterm and term infants without respiratory support. Statistical analysis, including regression analysis, Bland-Altman plots and cv-root-mean-square tests, was performed. A total of 188 duplicate (376 individual) measurements were collected from 119 infants (88 preterm, 31 term).
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