Publications by authors named "N Rincheval"

Article Synopsis
  • The study aimed to assess the effectiveness of the DAS28 γ-glutamyl transferase (DAS28-γGT) in predicting major cardiovascular events (MACE) in patients with rheumatoid arthritis (RA) from the ESPOIR cohort over 13 years.
  • Out of 696 RA patients, 34 experienced MACE, with a DAS28-γGT score above 9.4 being a strong indicator of higher risk, showing a hazard ratio of 3.11.
  • The findings suggest that DAS28-γGT is a valuable and straightforward tool for evaluating cardiovascular risk in RA patients, helping clinicians better identify those at potential risk for MACE.
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Article Synopsis
  • Diethylstilbestrol (DES) is a synthetic estrogen linked to adverse health effects in mothers, their children, and grandchildren due to its ability to cross the placenta and disrupt endocrine function.
  • A nationwide observational study analyzed data from 529 families of DES-treated women, focusing on pregnancy outcomes and birth weight variations across multiple generations.
  • Results showed that preterm birth rates increased significantly in children exposed to DES, but those born post-DES had a higher average birth weight compared to pre-DES neonates, with some slight increases in low birth weight among grandchildren of DES-exposed women.
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Article Synopsis
  • The study aimed to explore how social support, financial status, and lifestyle choices affect the level of disability in individuals with rheumatoid arthritis (RA).
  • Data were collected from the ESPOIR cohort, analyzing various factors like exercise, education, and financial situation to identify those with "excess disability."
  • Results showed that lower social support, worse financial conditions, less exercise, and lower education levels significantly correlated with higher disability, emphasizing the need for better economic and social support for RA patients.
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Article Synopsis
  • The study aimed to assess the predictive value of PROS (protein S) and CO7 (complement component C7) for response to methotrexate (MTX) and etanercept (ETA) treatment in rheumatoid arthritis (RA) patients.
  • RA patients from the ESPOIR cohort who received MTX with either ETA or adalimumab (ADA) were evaluated, measuring serum levels of PROS and CO7 before treatment.
  • Results showed that higher levels of PROS were associated with better response rates to MTX/ETA, making it a potential biomarker for predicting treatment effectiveness in this patient group.
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Article Synopsis
  • The study aimed to identify different groups of people with rheumatoid arthritis (RA) who experience varying levels of disability over 10 years, even if their inflammation levels are similar.
  • Data was collected from three European cohorts involving around 2500 participants, focusing on their disability (HAQ) and inflammation (DAS28-2C), as well as other factors like pain and mood.
  • The findings indicated that while inflammation control is important, it may not be enough to reduce disability for everyone with RA; addressing pain, fatigue, and mental health may be crucial for improving long-term functionality.
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