Publications by authors named "N Reidy"
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are filtered and secreted to their primary site of action in the proximal tubule of the kidney. At this site, SGLT2 inhibitors also reduce renal elimination of ketone bodies, a finding implicated in their propensity to cause ketoacidosis. Many commonly used medications have potential to diminish renal elimination of SGLT2 inhibitors and to compound the effects of SGLT2 inhibitors on renal elimination of ketone bodies by inhibiting tubular secretion of the SGLT2 inhibitor itself and/or ketone bodies.
View Article and Find Full Text PDFArticle Synopsis
- The BIOFIRE Joint Infection (JI) Panel uses multiplex-PCR testing to identify microorganisms in synovial fluid from patients suspected of septic arthritis and prosthetic joint infections.
- A study over 34 clinical sites in Europe and the Middle East indicated that the JI Panel showed 88.4% agreement in diagnosing septic arthritis and 85% for prosthetic joint infections when compared to traditional synovial fluid cultures.
- The JI Panel not only detected more positive samples, especially anaerobic bacteria, but also provided results in about one hour, improving patient management and treatment decisions.
Article Synopsis
- Septic arthritis is a severe illness often diagnosed through culture, but the recently approved BioFire® Joint Infection Panel (BJIP) offers a rapid alternative using synovial fluid.
- A study in the UK and Ireland showed that BJIP had a higher detection rate of positive results (98 vs 83) compared to routine cultures, with a positive percent agreement (PPA) of 91.6% and negative percent agreement (NPA) of 93%.
- The multidisciplinary team (MDT) discussed the BJIP's additional benefits, such as identifying antibiotic resistance and influencing treatment choices, while noting that it should complement standard methods and may have limitations regarding untested organisms.