Publications by authors named "N Rallon"
Elite controllers (ECs), a unique group of people with HIV (PWH), exhibit remarkable control of viral replication in the absence of antiretroviral therapy. In this study, we comprehensively characterized the NK cell repertoire in ECs after long-term viral control. Phenotypic profiling of NK cells revealed profound differences compared with other PWH, but marked similarities to uninfected individuals, with a distinctive prevalence of NKG2C+CD57+ memory-like NK cells.
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- HLA class I and KIR genotypes are known to affect HIV-1 disease progression and viral load, but their impact during primary infection is unclear.
- Previous studies have shown mixed results, suggesting that factors like the size of the virus dose and the route of infection (sexual vs. parenteral) may play a role.
- Our genome-wide association study found no evidence that the HLA/KIR system influences susceptibility to sexually transmitted HIV-1 infection, highlighting a separation between genetics related to viral load/progression and those related to HIV resistance.
Article Synopsis
- The study aimed to compare comorbidities and non-AIDS-related events between HIV-infected individuals and those with HIV/HCV coinfection in the context of modern therapies that don’t use interferon.
- A retrospective analysis of clinical records from Spanish patients revealed no significant differences in incidents of conditions like hypertension, diabetes, or cardiovascular disease between the two groups, suggesting that prior HCV exposure didn't impact health outcomes.
- Successful treatment of HCV with direct-acting antivirals (DAAs) showed promising results for improving health and survival rates in HIV/HCV-coinfected patients, emphasizing the need for early detection and treatment.
Elite controllers (ECs) are people living with HIV (PLWH) able to control HIV replication without antiretroviral therapy and have been proposed as a model of a functional HIV cure. Much evidence suggests that this spontaneous control of HIV has a cost in terms of T cell homeostasis alterations. We performed a deep phenotypic study to obtain insight into T cell homeostasis disturbances in ECs maintaining long-term virologic and immunologic control of HIV (long-term elite controllers; LTECs).
View Article and Find Full Text PDFElite controllers (ECs) are an exceptional group of people living with HIV (PLWH) that control HIV replication without therapy. Among the mechanisms involved in this ability, natural killer (NK)-cells have recently gained much attention. We performed an in-deep phenotypic analysis of NK-cells to search for surrogate markers associated with the long term spontaneous control of HIV.
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