Publications by authors named "N Rainy"

Biofilm formation and toxin production are some of the virulence factors of Clostridioides difficile (C. difficile), which causes hospital-acquired C. difficile infection (HA-CDI).

View Article and Find Full Text PDF

Background: The prevalence of community-acquired infection (CA-CDI) has been rising, due to changes in antibiotics prescribing practices, emergence of hypervirulent strains and improved diagnostics. This study explored CA-CDI epidemiology by examining strain diversity and virulence factors of CA-CDI isolates collected across several geographical regions in Israel.

Methods: Stool samples of 126 CA-CDI patients were subjected to PCR and an immunoassay to identify toxin genes and proteins, respectively.

View Article and Find Full Text PDF

Background: Viral infection is associated with a significant rewire of the host metabolic pathways, presenting attractive metabolic targets for intervention.

Methods: We chart the metabolic response of lung epithelial cells to SARS-CoV-2 infection in primary cultures and COVID-19 patient samples and perform in vitro metabolism-focused drug screen on primary lung epithelial cells infected with different strains of the virus. We perform observational analysis of Israeli patients hospitalized due to COVID-19 and comparative epidemiological analysis from cohorts in Italy and the Veteran's Health Administration in the United States.

View Article and Find Full Text PDF
Article Synopsis
  • The study compares the clinical features and outcomes of childhood-onset systemic lupus erythematosus (SLE) versus adult-onset SLE among Indonesian patients at tertiary care centers from 2008 to 2017.
  • It found that children with SLE presented more frequently with hematological disorders and arthritis at diagnosis, while adults more commonly exhibited skin issues like discoid rash and photosensitivity.
  • The research suggests that childhood-onset SLE may require a more aggressive treatment strategy due to a higher tendency for mortality and a different clinical profile compared to adult-onset SLE.
View Article and Find Full Text PDF