Paracetamol, its metabolites, and their transfer between maternal circulation and fetal brain in mono- and combination therapies.

Background: Due to its availability and perceived safety, paracetamol is recommended even during pregnancy and for neonates. It is used frequently alone or in combination with other drugs required for the treatment of various chronic conditions. The aim of this study was to investigate potential effects of drug interactions on paracetamol metabolism and its placental transfer and entry into the developing brain.

A Narrative Review of the Vulvar Disease Literature With Images of Women of Color.

Objective: To assess the existing literature on vulvar disease in women of color (WOC).

Methods: A narrative review was conducted to assess the literature on vulvar disease in WOC and evaluate the presence of images in this population. The search encompassed PubMed and OVID using relevant terms related to vulvar conditions and various groups of WOC.

Association between maternal schizophrenia and risk of serious asthma exacerbations in childhood.

Background And Hypothesis: While maternal schizophrenia is linked to chronic childhood medical conditions, little is known about the risk of acute asthma exacerbations among children whose mothers have schizophrenia. This population-based study used health data for all of Ontario, Canada to evaluate whether having a mother with schizophrenia was associated with increased risk of asthma exacerbations.

Study Design: The study cohort included 385,989 children diagnosed with asthma from age 2 years onward, followed from the time of their asthma diagnosis up to a maximum of age 19 years.

Effects of live yeast on milk yield, feed efficiency, methane emissions and fertility of high-yielding dairy cows.

Live yeast (Saccharomyces cerevisiae) products have the potential to increase milk yield of dairy cows in early lactation by improving rumen fermentation. Greater milk yields, however, are sometimes associated with poorer reproductive performance. This study aimed to assess the effect of a live yeast supplement on milk yield, methane emissions and reproduction indicators in high-yielding dairy cows.