10-Fold Increase in Hydrogen Atom Transfer Reactivity for a Series of = 1 Fe═O Complexes Over the = 2 [(TQA)Fe═O] Complex via Entropic Lowering of Reaction Barriers by Secondary Sphere Cycloalkyl Substitution.

Nonheme iron enzymes utilize = 2 iron(IV)-oxo intermediates as oxidants in biological oxygenations. In contrast, corresponding synthetic nonheme Fe═O complexes characterized to date favor the = 1 ground state that generally shows much poorer oxidative reactivity than their = 2 counterparts. However, one intriguing exception found by Nam a decade ago is the = 1 [Fe(O)(MeNTB)] complex (MeNTB = [tris((-methyl-benzimidazol-2-yl)methyl)amine], ) with a hydrogen atom transfer (HAT) reactivity that is 70% that of the = 2 [Fe(O)(TQA)] complex (TQA = tris(2-quinolylmethyl)amine, ).

An Online Mindfulness-based Intervention Decreases Stress, Anxiety, and Depression in Indian Healthcare Providers during the COVID-19 Pandemic: A Prospective Randomized Controlled Study.

Background: The coronavirus disease 2019 (COVID-19) pandemic contributed enormously to the psychosocial distress of Indian healthcare providers. The mental well-being of the healthcare community remains an underappreciated priority in India. The primary objective was to observe the results of an online brief mindfulness-based intervention on stress, anxiety, and depression, and the secondary objective was to examine its effects on mindfulness characteristics and World health Organization (WHO) quality of life among Indian healthcare providers during pandemic times.

Strong-field quantum control in the extreme ultraviolet domain using pulse shaping.

Tailored light-matter interactions in the strong coupling regime enable the manipulation and control of quantum systems with up to unit efficiency, with applications ranging from quantum information to photochemistry. Although strong light-matter interactions are readily induced at the valence electron level using long-wavelength radiation, comparable phenomena have been only recently observed with short wavelengths, accessing highly excited multi-electron and inner-shell electron states. However, the quantum control of strong-field processes at short wavelengths has not been possible, so far, because of the lack of pulse-shaping technologies in the extreme ultraviolet (XUV) and X-ray domain.

Synthesis of Thiazolidinedione- and Triazole-Linked Organoselenocyanates and Evaluation of Anticancer Activities Against Breast Cancer with Mechanistic Investigations.

Organoselenocyanates are important classes of organoselenium compounds having potential pharmaceutical applications in cancer biology. In the present study, two different series of organoselenocyanates (15 a-15 c and 16 a-16 c) incorporating crucial heterocyclic pharmacophores such as 2,4-thiazolidine-1,3-dione and 1,2,3-triazole were rationally designed. The organoselenocyanates were synthesized using multi-step organic synthesis and investigated for their anticancer activities against triple-negative breast cancer cells.