Publications by authors named "N R Pace"
Background: Social Determinants of Health (SDoH) continue to drive persistent disparities in perioperative care. Our team has previously demonstrated racial and socioeconomic disparities in perioperative processes, notably in the administration of antiemetic prophylaxis, in several large perioperative registries. Given how neighborhoods are socially segregated in the US, we examined geospatial clustering of perioperative antiemetic disparities.
View Article and Find Full Text PDFImportance: The conditions required for health record data sources to accurately assess treatment effectiveness remain unclear. Emulation of randomized clinical trials (RCTs) with health record data and subsequent calibration of the results can help elucidate this.
Objective: To pilot an emulation of the KEYNOTE-189 RCT using a commercially available electronic health record (EHR) data source.
Article Synopsis
- The study discusses the effective and selective synthesis of iminosugars, specifically 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) and lentiginosine, focusing on their seven stereoisomers.
- The starting material for these syntheses is 4-benzoyl-6-deoxy-6-iodoglycopyranosides, yielding between 38% to 68% for DAB and between 44% to 89% for lentiginosine.
- A key highlight of the process is a complex multistep reaction involving zinc-mediated reductive elimination, reductive amination, and intramolecular nucleophilic substitution, which allows for the